| Time Period | Reason for Vacancy |
|---|---|
| 1812-1813 | George Clinton died in office |
| 1814-1817 | Elbridge Gerry died in office |
| 1832-1833 | John C. Calhoun resigned from office |
| 1841-1845 | John Tyler became President upon the death of William Henry Harrison |
| 1850-1853 | Millard Fillmore became President upon the death of Zachary Taylor |
| 1853-1857 | William King died in office |
| 1865-1869 | Andrew Johnson became President upon the death of Abraham Lincoln |
| 1875-1877 | Henry Wilson died in office |
| 1881-1885 | Chester Arthur became President upon the death of James Garfield |
| 1885-1889 | Thomas Hendricks died in office |
| 1899-1901 | Garret Hobart died in office |
| 1901-1905 | Theodore Roosevelt became President upon the death of William McKinley |
| 1912-1913 | James S. Sherman died in office |
| 1923-1925 | Calvin Coolidge became President upon the death of Warren Harding |
| 1945-1949 | Harry Truman became President upon the death of Franklin D. Roosevelt |
| 1963-1965 | Lyndon Johnson became President upon the death of John F. Kennedy |
| 1973 | Spiro Agnew resigned from office |
| 1974 | Gerald Ford became President upon the resignation of Richard Nixon |